google scholar profile


  1. Grotzinger AD, Keller MC (2022). Potential bias in genetic correlations. Science, 378, 709-710.[Download PDF]
  2. Hatoum AS, Morrison CL, Mitchell EC, Lam M, Benca-Bachman CE, Reineberg AE, Palmer RHC, Evans LM, Keller MC, Friedman NP (2022). Genome-wide association study shows that executive functioning is influenced by GABAergic processes and is a neurocognitive genetic correlate of psychiatric disorders. Biological Psychiatry, 93, 59-70.[Download PDF]
  3. Balbona JV, Kim Y, Keller MC (2022). The estimation of environmental and genetic parental influences. Development and Psychopathology, in press.[Download PDF]
  4. Colbert S, Keller MC, Agrawal A, Johnson EC (2022). Exploring the relationships between autozygosity, educational attainment, and cognitive ability in a contemporary, trans-ancestral American sample. Behavior Genetics, 52, 315-323.[Download PDF]
  5. Saunders GRB, Wang X, ...[219 authors including Keller MC]... Vrieze SI (2022). Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature, in press.[Download PDF]
  6. Axelrud LK, Hoffman MS, Vosberg DE, Santoro M, Pan PM, Gadelha A, Belangero SI, Miguel EC, Shin J, Thapar A, Smoller JW, Pausova Z, Rohde LA, Keller MC, Paus R, Salum GA. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal of Child Psychology and Psychiatry, in press.[Download PDF]
  7. Jang S, Evans L... [61 authors]... Keller MC, Vrieze SI (2022). Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 Individuals. Nature Human Behavior, 6, 1577-1586.[Download PDF]
  8. Maitino AA, Rosenfarb IF, Glaser DN, Keller MC (2022). An evolutionary investigation of depressed mood: The relationship between daily stressors and patterns of depressive symptoms. Journal of Behavior Therapy and Experimental Psychiatry, 76: 101749.[Download PDF]
  9. Mallard TT, Linnér RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okbay A, de Vlaming R, Meddens SFW, Palmer AA, Davis LK, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP (2022). Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. Cell Genomics, 2: 100140.[Download PDF]
  10. Pardiñas AF...[32 authors including Keller MC]... Walters JTR, STRATA, Schizophrenia Working Group of the Psychiatric Genomics Consortium (2022). Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia. JAMA Psychiatry, 79, 26069.[Download PDF]
  11. Trubetskoy V...[94 authors including Keller MC]... ODonovan MC, Schizophrenia Working Group of the Psychiatric Genomics Consortium (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604, 5028.[Download PDF]
  12. Border R, ORourke S, de Candia T, Goddard ME, Visscher PM, Yengo L, Jones MC, Keller MC (2021). Assortative mating biases marker-based heritability estimators. Nature Communications, 13, 1-10.[Download PDF][Download Supplement]
  13. Howe LJ... [48 authors including Keller MC]...Davies NM (2021). Within Family GWAS Consortium. Within-sibship GWAS improve estimates of direct genetic effects. Nature Genetics, 54, 581-592.[Download PDF]
  14. Friedman NP, Banich MT, Keller MC (2021). Twin studies to GWAS: there and back again. Trends in Cognitive Science, 25, 855-869.[Download PDF]
  15. Sapin E, Keller MC (2021). Novel approach for parallelizing pairwise comparison problems as applied to detecting segments identical by decent in whole-genome data. Bioinformatics, 10, 2121-2125.[Download PDF]
  16. Evans LM, Jang S, Hancock DB, Ehringer MA, Otto JM, Vrieze SI, Keller MC (2021). Genetic architecture of four smoking behaviors using partitioned SNP heritability. Addiction, 116, 2498-2508.[Download PDF]
  17. Yengo L, Yang J, Keller MC, Goddard ME, Wray NR, Visscher PM (2021). Genomic partitioning of inbreeding depression in humans. American Journal of Human Genetics, 108, 1488-1501.[Download PDF]
  18. Lam M... [70 authors]... Keller MC, Andreasesen O, Deary I, Glahn D, Huang H, Liu C, Malhotra AK, Lencz T (2021). Identifying nootropic drug targets via large-scale cognitive GWAS transcriptomics. Neuropsychopharmacology, 46, 1788-1801.[Download PDF]
  19. Balbona JV, Kim Y, Keller MC (2021). Estimation of parental effects using polygenic scores. Behavior Genetics, 51, 264-278. [Won the Fulker Award for best paper published in Behavioral Genetics in 2021] [Download PDF] [Download Supplement][Download Univariate Algebra][Download Multivariate Algebra]
  20. Kim Y, Balbona JV, Keller MC (2021). Bias and precision of parameter estimates from models using polygenic scores to estimate environmental and genetic parental influences. Behavior Genetics, 51, 279-288.[Download PDF]
  21. Kemper KE, Yengo L, Zheng Z, Abdellaoui A, Keller MC, Goddard ME, Wray NR, Yang J, Visscher PM (2021). Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals. Nature Communications, 12, 1-11.[Download PDF]
  22. Keller MC (2020). Nick Martin as a mentor - a perspective. Twin Research and Human Genetics, 23, 112-113.[Download PDF]
  23. Evans LM, Johnson EC, Melroy-Grief WE, Hewitt JK, Hoeffer CA, Keller MC, Saba LM, Stitzel JA, Ehringer MA (2020). The role of a priori-identified addiction and smoking gene sets in smoking behaviors. Nicotine and Tobacco Research, 22, 1310-1315.[Download PDF]
  24. Yengo L, Sidari M, Verweij KJH, Visscher PM, Keller MC, Zietsch BP (2020). No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018). Behavioral Genetics, 50, 67-71. [Download PDF]
  25. Border R, Johnson EC, Evans LM, Keller MC (2019). Measurement Error Cannot Account for Failed Replications of Historic Candidate Gene-by-Environment Hypotheses. American Journal of Psychiatry, 176, 668-669.[Download PDF]
  26. Lam M... [67 authors including Keller MC]... Lencz T (2019). Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. American Journal of Human Genetics, 105, 334-350. [Download PDF]
  27. Huckins LM... [34 authors including Keller MC]... Stahl EA. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51, 659-674. [Download PDF]
  28. Border R, Johnson EC, Evans LM, Smolen A, Berley N, Sullivan PF, Keller MC. No support for historic candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples. American Journal of Psychiatry, 176, 376-387.[Download PDF][Download Supplement]
  29. Border R, Smolen A, Corley RP, Stallings MC, Brown SA, Conger RD, Derringer J, Donnellan MB, Haberstick BC, Hewitt JK, Hopfer C, Krauter K, McQueen MB, Wall TL, Keller MC, Evans LM. Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals. European Journal of Human Genetics, 27, 963-969.[Download PDF]
  30. Palmer RHC, Brick LA, Chou Y, Agrawal A, McGeary JE, Heath AC, Bierut L, Keller MC, Johnson E, Hartz SM, Schuckit MA, Knopik VS (2019). The etiology of DSM-5 alcohol use disorder: Evidence of shared and non-shared additive genetic effects. Drug and alcohol dependence, 201, 147-154.[Download PDF]
  31. Liu M… [139 authors, including Keller MC]… Vrieze S. Association studies of up to 1.2 million individuals yield new insights in the genetic etiology of tobacco and alcohol use. Nature Genetics, 51, 237-244. [Download PDF]
  32. Verhulst B, Prom-Wormley E, Keller MC, Medland S, Neale MC (2019). Type I Error Rates and Parameter Bias in Multivariate Behavioral Genetic Models. Behavioral Genetics, 49, 99-111. [Download PDF]
  33. Brick LA, Keller MC, Knopik VS, McGeary JE, Palmer RHC (2019). Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry. Addiction Biology, 24, 132-144. [Download PDF]
  34. Yengo L, Robinson MR, Keller MC, Kemper KE, Yang Y, Trzaskowski M, Gratten J, Turley P, Cesarini D, Benjamin DJ, Wray NR, Goddard ME, Yang J, Visscher PM (2018). Imprint of assortative mating on the human genome. Nature Human Behaviour, 2, 948-954. [Download PDF]
  35. Evans LM,Tahmasbi R, Vrieze SI, Abecasis G, Das S, Bjelland D,DeCandia T, Haplotype Reference Consortium, Goddard ME, Neale BM, Yang J, Visscher PM, Keller MC (2018). Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. Nature Genetics, 50, 737-745. [Download PDF]
  36. Evans LM, Tahmasbi R, Jones M, Vrieze SI, Abecasis GR, Das S, Bjelland DW, deCandia TR, Haplotype Reference Consortium, Yang J, Goddard ME, Visscher PM, Keller MC (2018). Narrow-sense heritability estimation of complex traits using identity-by-descent information. Heredity. [Download PDF]
  37. Evans LM, Keller MC (2018). Correspondence: Using partitioned heritability methods to explore genetic architecture. Nature Reviews Genetics, 19, 185. [Download PDF]
  38. Keller MC (in press).Evolutionary perspectives on genetic and environmental risk factors for psychiatric disorders. Annual Review Clinical Psychology. [Download PDF]
  39. Demmit BA, Corley RP, Huibregtse BM, Keller MC, Hewitt JK, McQueen MB, Knight R, McDermott I, Krauter KS (2017). BMC Genomics, 18, 659.[Download PDF]
  40. Johnson EC, Border R, Melroy-Greif WE, de Leeuw C, Ehringer MA, Keller MC (2017). No evidence that schizophrenia candidate genes are more associated with schizophrenia than non-candidate genes. Biological Psychiatry, 82, 702-708. [Download PDF] [Download Commentary on this paper]
  41. Brick LA, Keller MC, Knopik VS, McGeary JE, Palmer RHC (2017). Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry. Addiction Biology. [Download PDF]
  42. Lam M, Trampush JW, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Chiba-Falek O, Attix DK, Need AC, Cirulli ET,  Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T (2017). Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell reports, 21, 2597-2613. [Download PDF]
  43. Border R & Keller MC (2017). Fundamental problems with candidate gene-by-environment interaction studies. Journal of Child Psychology and Psychiatry, 58, 328-330. [Download PDF]
  44. Lee AJ, Wright MJ, Martin NG, Keller MC, Zietsch BP (2017). Facial trustworthiness is associated with heritable aspects of face shape.Adaptive human behavior and physiology, 3, 351-364.
  45. Bjelland DW, Lingala U, Patel PS, Jones M, Keller MC (2017). A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data. European Journal of Human Genetics, 25, 617-624. [Download PDF]
  46. Lee AJ, Hibbs C, Wright MJ, Martin NG, Keller MC, Zietsch BP (2017). Assessing the accuracy of perceptions of intelligence based on heritable facial features. Intelligence, 64, 1-8.[Download PDF]
  47. Trampush JW, Yang MLZ, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S,  Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold A, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Goldstein DB, Voineskos AN, Stefanis NC, Bilder RM, Scult M, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri A, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T (accepted). GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: A report from the COGENT consortium. Molecular Psychiatry, 22, 336-345. [Download PDF]
  48. Liu M, Malone SM, Vaidyanathan U, Keller MC, McGue M, Iacono WG, Vrieze SI (accepted). Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Psychological Medicine, 47, 1116-1125. [Download PDF]
  49. Johnson EC, Bjelland DW, Howrigan DP, Abdellaoui A, Breen G, Borglum A, Cichon S, Degenhardt F, Forstner AJ, Frank J, Genovese G, Heilmann-Heimbach S, Herms S, Hoffman P, Maier W, Mattheisen M, Morris D, Mowry B, Müller-Mhysok G, Neale BM, Nenadic I, Nöthen MM, O’Dushlaine D, Rietschel M, Ruderfer DM, Rujescu D,  Schulze TG, Simonson MA, Stahl E, Strohmaier J, Witt SH, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Keller MC (2016). No Reliable Association Between Runs Of Homozygosity And Schizophrenia In A Well-Powered Replication Study. PLoS Genetics, 12, e1006343.[Download PDF]
  50. Tahmasbi R, Keller MC. GeneEvolve: a fast and memory efficient forward-time simulator of realistic whole-genome sequence and SNP data (2016). Bioinformatics. [PMCID in progress][Download PDF].
  51. Howrigan D, Simonson MA, Davies G, Harris SE, Tenesa A, Starr JM, Liewald DC, Deary IJ, McRae A, Wright MJ, Montgomery GW, Hansell N, Martin NG, Payton A, Horan M, Ollier WE, Abdellaoui A, Boomsma DI, DeRosse P, Knowles EEM, Glahn DC, Djurovic S, Melle I, Andreassen OA, Christoforou A, Steen VM, Hellard SL, Sundet K, Reinvang I, Espeseth T, Lundervold AJ, Giegling I, Konte B, Hartmann AM, Rujescu D, Roussos P, Giakoumaki S, Burdick KE, Bitsios P, Donohoe G, Corley RP, Visscher PM, Pendleton N, Malhotra K, Neale BM, Lencz T, Keller MC (2016). The impact of genome-wide autozygosity on general cognitive ability. Molecular Psychiatry, 21, 837-843. [PMCID: PMC4803638][Download PDF]
  52. Lee AJ, Mitchem DG, Wright MJ, Martin NG, Keller MC, & Zietsch BP (2016). Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect. Evolution and Human Behavior, 37, 61-66. [PMCID: PMC4743547][Download PDF]
  53. Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, Fanous A, Keller MC, Castelao E, Kutalik Z, der Auwera SV, Homuth G, Nauck M, Teumer A, Milaneschi Y, Hottenga J, Direk N, Hofman A, Uitterlinden A, Mulder CL, Henders AK, Medland SE, Gordon S, Heath AC, Madden PAF, Pergadia ML, van der Most PJ, Nolte IM, van Oort FVA, Hartman CA, Oldehinkel AJ, Preisig M, Grabe HJ, Middeldorp CM, Penninx BWJH, Boomsma D, Martin NG, Montgomery G, Maher BS, van den Oord EJ, Wray NR, Tiemeier H, Hettema JM (2016). Meta-analysis of genome-wide studies of anxiety disorders. Molecular Psychiatry, 1-9. [PMCID: 4940340][Download PDF]
  54. Palmer RHC, Nugent NR, Brick LA, Bidwell CL, McGeary, J. E., Keller MC, Knopik VS (2016). Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users (2016). Journal of Traumatic Stress, 29, 197–204. [PMCID in progress][Download PDF]
  55. Lee SJ, Byrne EM, ...[183 authors including Keller MC]... van RielInt P (2015). New data and an old puzzle: The negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology, 44(5), 1706–1721. [PMCID: PMC4881824][Download PDF]
  56. Yang J, Bakshi A, Zhu Z, Hemani G, Vinkhuyzen AAE, Hong Lee S, Robinson, MR, Perry JRB, Nolte IM, Van Viliet-Ostaptchouk JV, Snieder H, The LifeLines Cohort Study, Esko T, Milani L, Magi R, Metspalu A, Hamsten A, Magnusson PKE, Pedersen NL, Ingelsson E, Soranzo N, Keller MC, Wray NR, Goddard ME, Visscher PM (2015). Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47(10), 1114-20 [PMCID: PMC4589513][Download PDF]
  57. Palmer RHC, McGeary JE, Heath AC, Keller MC, Brick LA, Knopik VS (2015). Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry. Addiction, 110, 1922-1931 [PMCID: PMC4644467][Download PDF]
  58. Mitchem DG, Zietsch BP, Wright MJ, Martin NG, Hewitt J, Keller MC (2015). No relationship between intelligence and facial attractiveness in a large, genetically informative sample. Evolution and Human Behavior, 36, 240-247. [PMCID: PMC4415372][Download PDF]
  59. Keller MC, Visscher PM (2015). Genetic variation links creativity to psychiatric disorders. Nature Neuroscience, 18(7), 928-929. [Download PDF]
  60. Haysom HJ, Mitchem DG, Lee AJ, Wright MJ, Martin NG, Keller MC, Zietsch, BP (2015). A test of the facultative calibration/reactive heritability model of extraversion. Evolution and Human Behavior, 36, 414-419.[Download PDF]
  61. Derringer J, Corley RP, Haberstick BC, Young SE, Demmitt BA, Howrigan DP, Kirkpatrick RM, Iacono WG, McGue M, Keller MC, Brown S, Tapert S, Hopfer CJ, Stallings MC, Crowley TJ, Rhee SH, Krauter K, Hewitt JK, McQueen MB (2015). Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. Behavioral Genetics, 45(4), 375-81.[Download PDF]
  62. Trampush JW, Lencz T, Knowles E, Davies G, Guha S, Pe'er I, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Scult M, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri A, Weinberger DR, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK (2015). Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 168, 363-373.[Download PDF]
  63. Palmer RHC, Brick L, Nugent NR, Bidwell LC, McGeary JE, Knopik VS, Keller MC (2015). Examining the role of common genetic variants on alcohol, tobacco, cannabis, and illicit drug dependence. Addiction, 110, 530-537. [PMCID: PMC 4329043][Download PDF]
  64. Dick DM, Agrawal A, Keller MC , Adkins A, Aliev F, Monroe S, Hewitt JK, Kendler KS, Sher KJ, (2015). Candidate Gene-Environment Interaction Research: Reflections and Recommendations. Perspectives on Psychological Science, 10, 37-59. [PMCID: PMC4302784][Download PDF]
  65. Zietsch BP, de Candia TR, & Keller MC (2015). Evolutionary behavioral genetics. Current Opinion in Behavioral Sciences, 2, 73-80. [PMCID: 4288764][Download PDF]
  66. Verweij KJH, Abdellaoui A, Veijola J, Sebert S, Koiranen M, Keller MC, Jarvelin M, Zietsch BP (2014). The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits. PLoS One, 9, e103102. [PMCID: 4111285][Download PDF]
  67. The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Biological insights from 108 schizophrenia-associated genetic loci. (2014). Nature, 511, 421-427. [PMCID: 4112379][Download PDF]
  68. Gratten J, Wray NR, Keller MC, & Visscher PM (2014). Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nature Neuroscience, 17, 782-790. [PMCID: 4112149][Download PDF]
  69. Power RA, Keller MC, Wray NR, Lewis CM, Sullivan PF, MDD PGC Working Group, Breen G (2014). A recessive genetic model and runs of homozygosity in major depressive disorder. Neuropsychiatric Genetics, 165, 157-166. [PMCID: 4234115][Download PDF]
  70. Malhotra A, Lencz T, Knowles E, Glahn D, Keller MC, Burdick K, Guha S, Mukherjee S, John M, Roussos P, Deary I, Davies G, Liewald D, Starr J, Andreassen O, Djurovic R, Melle I, Sundet K, Le Hellard S, Christoforou A, Espeseth T, Reinvang I, Lundervold A, Steen V, Darvasi A, Bitsios P, Giakoumaki S, Iwata N, Ikeda M, Rujescu D, Giegling I, Lahti J, Räikkönen K, Widen E, Palotie A, Eriksson J, Konte B, Donohoe G, Corvin A, Morris D, Gill M, Pendleton N, Payton A, Ollier W & Horan M (2014). Molecular Evidence for Genetic Overlap between General Cognitive Ability and Risk for Schizophrenia: A Report from the Cognitive Genomics Consortium (COGENT). Molecular Psychiatry, 19, 168-174. [PMCID: 3968799][Download PDF]
  71. Mitchem DG, Purkey AM, Grebe NM, Carey G, Garver-Apgar CE, Bates TC, Arden R, Hewitt JK, Medland SE, Martin NG, Zeitsch BP, & Keller MC (2014). Estimating the sex-specific effects of genes on facial attractiveness and sexual dimorphism. Behavior Genetics, 44, 270-281. [PMCID: 4096150][Download PDF]
  72. Lee AJ, Mitchem DG, Wright MJ, Martin NG, Keller MC & Zietsch BP (2014). Genetic factors that increase male facial masculinity decrease facial attractiveness of female relatives. Psychological Science, 25, 476-484. [PMCID: 4205959][Download PDF]
  73. Simonson MA, McQueen MB, & Keller MC (2014). Whole-genome pathway analysis of 132,497 individuals identifies novel gene-sets associated with body mass index. PLoS One, 9, e78546. [PMCID: 3908858][Download PDF]
  74. Keller MC (2014). Gene-by-environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution. Biological Psychiatry, 75, 18-24. [PMCID: 3859520] [Download PDF]
  75. de Candia, T., Lee, S. H., Yang, N. R., Browning, B., Gejman, P. V., Levinson, D. F., Mowry, B. J., Hewitt, J. K., Goddard, M. E., O’Donovan, M. C., Purcell, S., Posthuma, D., International Schizophrenia Consortium, Molecular Genetics of Schizophrenia Consortium, Visscher, P. M., Wray, N. R., & Keller, M. C. (2013). Additive genetic variation in risk to schizophrenia shared between populations of African and European descent. American Journal of Human Genetics, 93, 463-470. [Download PDF]
  76. Cross-disorder group of the Psychiatric Genomics Consortium (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45, 984-994.[Download PDF]
  77. Keller, M. C., Garver-Apgar, C. E., Wright, M. J., Martin, N. G., Corley, R. P., Stallings, M. C., Hewitt, J. H., Zietsch, B. P. (2013). The genetic correlation between height and IQ: Shared genes or assortative mating? PLoS Genetics, 9(4), e1003451. [Download PDF]
  78. Verweij, K. J. H., Yang, J., Lahti, J, Veijola, J., Hintsanen, M., Pulkki-Råback, L., Heinonen,K., Pouta, A., Pesonen, A. K., Widen, E., Taanila, A., Isohanni, M., Miettunen, J., Palotie, A., Penke, L., Service, S. K., Heath, A. C., Montgomery, G. W., Raitakari, O., Kähönen, M., Viikari, J., Räikkönen, K., Eriksson, J. G., Keltikangas-Järvinen, L., Lehtimäki, T., Martin, N. G., Järvelin, M.R., Visscher, P.M., Keller, M.C., & Zietsch, B. P. (2012). Maintenance of genetic variation in human personality: Testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution, 6, 3238-3251.[Download PDF]
  79. Keller, M. C., Simonson, M. A., Ripke, S., Neale, B. M., Gejman, P. V., Howrigan, D. P., Lee, S. H., Lencz, T., Levinson, D. F., Sullivan, P. F., & The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2012). Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genetics, 8, e1002656. [Download PDF] [Download analysis script]
  80. Lee, S. H., DeCandia, T., Ripke, S., Yang, J., PGC-SZ, ISC, MGS, Sullivan, P. S., Goddard, M. E., Keller, M. C., Visscher, P. M., & Wray, N. R. (2012). Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nature Genetics, 44, 247-250. [Download PDF]
  81. Visscher, P. M. & Keller, M. C. (2011). (Mis)understanding heritability. European Journal of Personality, 25, 285-286.[Download PDF]
  82. The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011). Genome-wide association study identifies five novel schizophrenia loci. Nature Genetics, 43, 969-976.[Download PDF]
  83. Simonson, M. A., Wills, A. G., Keller, M. C., & McQueen, M. B. (2011). A comprehensive approach assessing the contribution of polygenic variation to risk of cardiovascular disease, BMC Medical Genetics, 12, 146. [Download PDF]
  84. Howrigan, D. P, Simonson, M. A, & Keller, M. C. (2011). Detecting autozygosity using runs of homozygosity: A comparison of three autozygosity detection algorithms. BMC Genomics, 12, 460-475.[Download PDF]
  85. Keller, M. C., Visscher, P. M., & Goddard, M. E. (2011). Quantification of inbreeding due to distant ancestors and its detection using dense SNP data. Genetics, 189, 237-249. [Download PDF]
  86. Duncan, L. E. & Keller, M. C. (2011). A critical review of the first ten years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 1041-1049.[Download PDF]
  87. Howrigan, D. P., Simonson, M. A., Kamens, H. M., Stephens, S. H., Wills, A. G., Ehringer, M. A., Keller, M. C., & McQueen, M. B. (2011). Mutational load analysis of unrelated individuals. BMC Proceedings, 5.[Download PDF]
  88. Keller, M. C., Medland, S. E., & Duncan, L. E. (2010). Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models. Behavior Genetics, 40, 377-393.[Download PDF] [Won the Fulker Award for best paper published in Behavioral Genetics in 2010]
  89. Hatemi, P. K., Medland, S. E., Keller, M. C., Martin, N. G., Hibbing, J. R., Smith, K., Alford, J. R. & Eaves L. J. (2010). Not by twins alone: Using the extended family design to investigate genetic influence on political beliefs. American Journal of Political Science, 54, 798-814.[Download PDF]
  90. Keller, M. C., Howrigan, D. P., & Simonson, M. A. (2009). Theory and methods in evolutionary behavioral genetics. To appear in D. Buss & P. Hawley (eds.), Evolution of personality and individual differences.[Download PDF]
  91. Keller, M. C., McCrae, A. F., McGaughran, J. M., Visscher, P. M., Martin, N. G., & Montgomery, G. W. (2009). Non-pathological paternal isodisomy of chromosome 2 detected from a genome-wide SNP scan. American Journal of Medical Genetics Part A,149, 1823-1826. [Download PDF]
  92. Keller, M. C., Medland, S. E., Duncan, L. E., Hatemi, P. K., Neale, M. C., Maes, H. H. M., & Eaves, L. J. (2009). Modeling extended twin family data I: Description of the Cascade model. Twin Research and Human Genetics, 29, 8-18.[Download PDF][Full Cascade Algebra][Path Diagram]
  93. Medland, S. E., & Keller, M. C. (2009). Modeling extended twin family data II: Power associated with different family structures. Twin Research and Human Genetics, 29, 19-25.[Download PDF][Mx Cascade Script]
  94. Maes, H. H., Neale, M. C., Medland, S. E., Keller, M. C., Martin, N. G., Heath, A. C., & Eaves, L. J. (2009). Flexible Mx specifications of various extended twin kinship designs. Twin Research and Human Genetics, 26-34.[Download PDF]
  95. Keller, M. C. (2008). The evolutionary persistence of genes that increase mental disorder risk. Current Directions of Psychological Science, 17, 395-399. [Download PDF]
  96. Zietsch, B. P., Morley, K. I., Shekar, S. N., Verweij, K. J. H., Keller, M. C., Macgregor, S., Wright, M. J., Bailey, J. M., & Martin, N. G. (2008). Genetic factors predisposing to homosexuality may increase mating success in heterosexuals. Evolution and Human Behavior, 29, 424-433.[Download PDF]
  97. Medland, S. E., Loehlin, J. C., Willemsen, G., Hatemi, P. K., Keller, M. C., Boomsma, D. I., Eaves, L. J., & Martin, N. G. (2008). Males do not reduce the fitness of their female co-twins in contemporary samples. Data from Australia, the Netherlands, and the United States. Twin Research and Human Genetics, 11, 481-487. [Download PDF]
  98. Keller, M. C. (2008). Problems with the imprinting hypothesis of schizophrenia and autism [Commentary]. Brain and Behavioral Sciences, 31, 241-320. [Download PDF]
  99. Keller, M. C. (2008). An evolutionary genetic framework for heritable disorders. Encyclopedia of Life Sciences (ELS). John Wiley & Sons Ltd: Chicester. [Download PDF]
  100. Keller, M. C. (2008). Dr. Keller replies [Response to Letter], American Journal of Psychiatry, 165, 533-534. [Download PDF]
  101. Ybarra, O., Burnstein, E., Winkielman, P., Keller, M. C., Manis, M., Chan, E., & Rodriguez, J. (2008). Mental exercising through simple socializing: Social interaction promotes general cognitive functioning. Personality and Social Psychology Bulletin, 34, 248-259. [Download PDF]
  102. Keller, M. C., Neale, M. C., & Kendler, K. S. (2007). Different negative life events are associated with different patterns of depressive symptoms. American Journal of Psychiatry, 164, 1521-1529. [Download ALE Coding Book][Download PDF][Selected by the editors as a notable paper of 2007]
  103. Keller, M. C. (2007). The role of mutations in human mating. In G. Geher & G. Miller (Eds.), Mating intelligence: Theoretical, experimental, and differential perspectives. Lawrence Erlbaum: Mahwah, NJ. [Download PDF]
  104. Keller, M. C. (2007). Standards of evidence in the nascent field of evolutionary behavioral genetics [Commentary]. European Journal of Personality, 21, 608-610.[Download PDF]
  105. Ybarra, O., Keller, M. C., Chan, E., Baron, A. S., Hutsler, J., Garcia, S. M., Sanchez-Burks, J., & Morrison, K. R. (2007). The social prediction dynamic: A legacy of cognition and mixed motives. In J. P. Forgas, M. G. Haselton, & W. von Hippel (Eds.), Evolution and the Social Mind. Psychology Press: New York. [PDF available soon]
  106. Keller, M. C., & Miller, G. F. (2006). Resolving the paradox of common, harmful, heritable mental disorders: Which evolutionary genetic models work best? Behavioral and Brain Sciences, 29, 385-452. [Download PDF: Target Article + Comments + Response][One of 7 Editor’s Choice Article in last 4 years]
  107. Keller, M. C., & Miller, G. F. (2006). An evolutionary framework for mental disorders: Integrating adaptationist and evolutionary genetic models. [Response to commentaries]. Behavioral and Brain Sciences, 29, 429-441. [For PDF, see reference immediately above]
  108. Keller, M. C., & Nesse, R. M. (2006). The evolutionary significance of depressive symptoms: Different life events lead to different depressive symptom patterns. Journal of Personality and Social Psychology, 91, 316-330. [Download PDF]
  109. Cannon, T., & Keller, M. C. (2006). Endophenotypes in the genetic analyses of mental disorders. Annual Review of Clinical Psychology, 2, 267-290. [Download PDF]
  110. Keller, M. C., Coventry, W. L., Heath, A. C., & Martin, N. G. (2005). Widespread evidence for non-additive genetic variation in the Cloninger and Eysenck personality dimensions using a twin plus sibling design. Behavior Genetics, 35, 707-721. [Download PDF]
  111. Keller, M. C., Fredrickson, B. L., Ybarra, O., Cote, S., Johnson, K., Mikels, J., Conway, A., & Wager, T. (2005). A warm heart and a clear head: The contingent effects of weather on human mood and cognition. Psychological Science, 16, 724-731. [Download PDF ]
  112. Keller, M. C. & Coventry, W. L. (2005). Quantifying and addressing parameter indeterminacy in the classical twin design. Twin Research and Human Genetics, 8, 201-213. [Download PDF]
  113. Coventry, W. L. & Keller, M. C. (2005). Estimating the extent of parameter bias in the classical twin design: A comparison of parameter estimates from the extended twin-family and classical twin designs. Twin Research and Human Genetics, 8, 214-223. [Download PDF]
  114. Wager, T., Keller, M. C., Jonides, J., Smith, O., & Lacey, S. (2005). Increased sensitivity in neuroimaging analyses using robust regression. NeuroImage, 26, 99-113. [Download PDF]
  115. Keller, M. C., & Nesse, R. M. (2005). Is low mood an adaptation? Evidence for subtypes with symptoms that match precipitants. Journal of Affective Disorders, 86, 27-35. [Download PDF]
  116. Keller, M. C. (2004) Evolutionary explanations of schizophrenia must ultimately explain the genes that predispose to it [Commentary]. Behavioral and Brain Sciences, 27, 861-862. [Download PDF]
  117. Keller, M. C., Nesse, R. M., & Hofferth, S. (2001). The Trivers-Willard effect in parental investment: No effect in the contemporary U.S. Evolution and Human Behavior, 22, 343-360. [Download PDF]
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